ARVO reflects growing role of AO imaging in retinal degeneration
24.04.2024
We are pleased to announce a series of presentations at ARVO 2025 of recent studies that have used Imagine Eyes’ adaptive optics (AO) retinal cameras to provide new, relevant insights into retinal degenerative diseases. These studies demonstrate the versatility and precision of AO imaging, particularly in providing detailed phenotypic analysis and tracking disease progression.
Stephenson et al. obtained detailed characterizations of cone photoreceptor mosaics in patients with PRPF31-associated dominant retinitis pigmentosa, revealing microstructural abnormalities even in asymptomatic individuals. Van den Broeck et al. used AO imaging to investigate deep phenotypes in RPE65-related maculopathy, shedding light on the specific macular lesions that cause vision loss. A study by Markle et al. in dry AMD demonstrated the ability of AO retinal cameras to visualize and analyze hyporeflective clumps (HRCs) associated with the progression of geographic atrophy.
AO imaging with the rtx1 camera was also instrumental in the KEYS natural history study of EYS-associated retinitis pigmentosa. In a subset of KEYS, Hiraoka et al. found that longitudinal changes in cone density were correlated with loss of visual function. In another related sub-study, Gocho et al. reported solid data demonstrating the ability of AO cameras to measure retinal changes over shorter time frames compared to traditional imaging such as OCT.
Finally, as an outcome of the AO-Vision collaborative project to develop AI retinal biomarkers based on AO imaging, Andrade et al. demonstrated that consistent image quality is essential for accurate cone density measurements and reproducible results, emphasizing the importance of standardized imaging protocols. This study had a positive impact on the Imagine Eyes rtx1 AO camera, which now integrates a set of standardized protocols with fast workflows.
Visit us at ARVO booth #1409 if you’d like to try out the rtx1 equipped with fast protocol workflows, as well as AO-Vision’s new AI analytics.
These studies underscore AO’s growing role in advancing the understanding of retinal disease, improving diagnostic accuracy, and providing a platform to monitor disease progression in short time frames with unmatched precision. We can’t wait to hear their presentations at ARVO!
References and Schedule information
Markle et al. Morphometric analysis of the near-infrared hypo-reflective clumps associated with late-stage AMD in Flood Illumination Adaptive Optics (FIAO). Session: High Resolution Imaging and Clinical Applications. Poster #A0130, hall A-E. Sun, May 4 | 3:15pm – 5:00pm
Stephenson et al. R Deep phenotyping of PRPF31-associated Dominant Retinitis Pigmentosa. Session: Retinitis pigmentosa and IRD. Poster #A0017, hall A-E. Mon, May 5, 8:30am – 10:15am
Andrade De Jesus et al. The Influence of Image Quality on Cone Density Measurements in Adaptive Optics Flood Illumination Ophthalmoscopy. Session: Adaptive optics, microscopy, MRI, ultrasound, and other imaging technologies. Poster #A0060, hall A-E. Mon, May 5, 3:00pm – 4:45pm.
Van den Broeck et al. In-depth phenotypic study of a Novel Autosomal Dominant RPE65-related Retinal Dystrophy. Session: Retinitis pigmentosa and IRD II. Poster #B0158, hall A-E. Tue, May 6, 8:30am – 10:15am
Gocho et al. A two-year prospective natural history study of EYS-associated retinitis pigmentosa (KEYS study): assessment of progression using OCT and adaptive optics. Session: Retinitis pigmentosa and IRD II. Poster #B0171, hall A-E. Tue, May 6, 8:30am – 10:15am.
Hiraoka et al. Correlation Between Cone Density and Visual Function in 27 EYS-RP Patients Using AO Fundus Camera: A Subset Analysis of the KEYS Study. Session: Retinitis pigmentosa and IRD II. Poster #B0199, hall A-E. Tue, May 6, 8:30am – 10:15am.
